Mine Health and Safety Act, 1996 (Act No. 29 of 1996)

Notices

Guidance Note for a Management and Control Programme for Tuberculosis in the South African Mining Industry

Part B : Author's Guide

6. Treatment regimens
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These should be strictly as recommended in the NTBMG (as set out below).

 

REGIMEN 1: For new patients and previously treated

Pre-treatment

body weight

Intensive Phase

7 days a week for 2

months

Continuation phase

7 days a week for 4 months

RHZE

(150,75,400,275)

RH

(150,75)

RH

(300,150)

30-37 kg

2 tabs

2 tabs

 

38-54 kg

3 tabs

3 tabs

 

4 tabs

 

2 tabs

>70kg

5 tabs

2 tabs

 

NOTE: Where NAT is used and the result is Rifampicin susceptible then Regimen 1 should be used for both new and previously treated patients. Where the NAT result is Rifampicin resistant, the patient should be started on MDR-TB treatment. All Rifampicin resistant patients should have a culture and first line DST conducted to confirm MDR-TB. The dosages may be adjusted based on changes in weight.