INTRODUCTION
The competencies required in the domain to implement processes to prevent and manage drug interactions, adverse drug reactions and drug resistance are:
| 5.1 | Understand the importance of drug interactions, e.g. drug/drug and drug/disease; |
| 5.2 | Demonstrate in-depth knowledge of various ART drug interactions and reactions; |
| 5.3 | Prevent adverse drug interactions and reactions; and |
| 5.4 | Define the types and consequences of drug resistance. |
DOMAIN 5: IMPLEMENT PROCESSES TO PREVENT AND MANAGE DRUG INTERACTIONS, ADVERSE DRUG REACTIONS AND DRUG RESISTANCE
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COMPETENCIES
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BEHAVIOURAL STATEMENTS
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| 5.1 | Understand the importance of drug interactions, e.g. drug/drug and drug/disease |
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| 5.1.1 | Understanding the basics of drug interactions. |
| 5.1.2 | Listing and describing the consequences of drug interactions. |
Range: therapeutic failure, drug resistance, life-threatening toxicities, poor adherence, increased costs.
| 5.1.3 | Demonstrating knowledge and understanding of how the body processes drugs and of specified pharmacological concepts. |
Range: pharmacokinetics and pharmacodynamics, therapeutic index, substrate, inhibitor, inducer.
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| 5.2 | Demonstrate in-depth knowledge of various ART drug interactions and reactions |
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| 5.2.1 | Listing the ARVs most involved in drug interactions. |
| 5.2.2 | Describing medicines that may interact with ART and understand their mode of interaction and the management of interaction. |
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| 5.3 | Prevent adverse drug interactions and reactions |
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| 5.3.1 | Knowing how to prevent drug interactions. |
Range: Comprehensive patient questioning and accessing useful resources.
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| 5.4 | Define the types and consequences of drug resistance |
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| 5.4.1 | Demonstrating an understanding of the consequences of drug resistance. |
| 5.4.2 | Demonstrating an understanding of the mechanism of HIV drug resistance. |
| 5.4.3 | Defining acquired drug resistance, transmitted drug resistance, and pre-treatment drug resistance in patients. |
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